Pronounced Hypoperfusion during Spreading Depression in Mouse Cortex
نویسندگان
چکیده
منابع مشابه
Pronounced hypoperfusion during spreading depression in mouse cortex.
We studied unique cerebral blood flow (CBF) responses to cortical spreading depression in mice using a novel two-dimensional CBF imaging technique, laser speckle flowmetry. Cortical spreading depression caused a triphasic CBF response in both rat and mouse cortex. In rats, mild initial hypoperfusion (approximately 75% of baseline) was followed by a transient hyperemia reaching approximately 220...
متن کاملP85: Spreading Depression in the Brain Cortex and Spinal Cord
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متن کاملp85: spreading depression in the brain cortex and spinal cord
cortical spreading depression (csd) has been suggested to underlie some neurological disorders such as migraine. despite the intensity with which many investigators have studied sd in the brain, only a few studies have aimed to identify sd in the spinal cord. here we described the main characteristic features of sd in the spinal cord induced by different methods including various spinal cord in...
متن کاملProtective effect of ifenprodil against spreading depression in the mouse entorhinal cortex.
In the brain, spreading depression (SD) is characterized by a large extracellular DC shift, a massive failure of ion homeostasis and a transient cessation of neuronal function. Clinically, SD is believed to be involved in various neurological disorders including migraine and cerebrovascular diseases. The propagation of cortical SD requires the release of glutamate, and N-methyl-D-aspartate (NMD...
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ژورنال
عنوان ژورنال: Journal of Cerebral Blood Flow & Metabolism
سال: 2004
ISSN: 0271-678X,1559-7016
DOI: 10.1097/01.wcb.0000137057.92786.f3